8. Potential value of
8-A. Scientific and Technological Values
scientific method: The
coherent multidimensional spectroscopic methods that have been and will be
theoretically proposed by the CMDS can serve as new analytical tools. In analogy
with 2D-NMR that was developed from the 1D-NMR technique, the coherent
multidimensional spectroscopy, unlike the 1D vibrational spectroscopies, will be
used not only for analyzing minute amount of biological material but also for
determining 3D molecular structure and dynamics. Novel scientific tool will
bring revolutionary scientific and technological breakthroughs in understanding
chemical and biological phenomena.
description of biological processes:
Enzyme catalysis, protein folding, and ligand-protein binding process are key
research subjects that have attracted chemists and biologists. One can claim
that one of these phenomena is completely understood only when it is described
in terms of molecular and electronic structural changes as a function of time.
The time-resolved coherent multidimensional spectra revealing snap-shot
structures of molecular species will provide the most direct information on the
real-time picture of all these bio-scientific processes.
(Humane Genome) Project:
Coherent multidimensional spectroscopy will be the central tool that is capable
of characterizing equilibrium 3D protein structure as well as studying protein
folding mechanism. This is the central theme of proteomics, which is one
of the post-HG projects.
8-B. Socio-Economic Value
Ultimately, the proposed research project will answer a number of critical
questions on chemical processes of living. Thus, the research outcome will
initiate new industrial development of medical and analytical instruments.
Applying these methods to study environmental pollution problems, one will be
able to provide a better solution for those environmental